Dem
47
GOP
53
Each party has lists of the members of the House and Senate that it thinks are most vulnerable and who will be specifically targeted. The Republicans' list of candidates trying to knock off the weakest House Democrats used to be called the "Young guns." This year the list was renamed the MAGA Majority Program, but it is the same thing. Here is the list (asterisks denote that the PVI was before the midcycle redistricting):
| District | PVI | Incumbent | Challenger | Challenger's background |
| AZ-01 | R+1 | (Open) | Jay Feely (R) | Former NFL kicker |
| CA-13 | R+1* | Adam Gray (D) | Kevin Lincoln (R) | Former mayor of Stockton |
| IA-02 | R+4 | (Open) | Joe Mitchell (R) | Former state representative |
| ME-02 | R+4 | (Open) | Paul LePage (R) | Former governor of Maine |
| NC-01 | R+1* | Don Davis (D) | Laurie Buckhout (R) | Retired Army colonel |
| NY-03 | EVEN | Tom Suozzi (D) | Mike LiPetri (R) | Former state assemblyman |
| NY-19 | D+1 | Josh Riley (D) | Peter Oberacker (R) | State senator |
| TX-28 | R+2* | Henry Cuellar (D) | Tano Tijerina (R) | Webb County executive |
| TX-34 | EVEN* | Vicente Gonzalez (D) | Eric Flores (R) | Army veteran |
These will certainly be among the most competitive districts this fall. (V)