| Senator | State | Party | Reelect |
| Jeff Sessions | Alabama | GOP | 2014 |
| Richard Shelby | Alabama | GOP | 2016 |
| Lisa Murkowski | Alaska | GOP | 2016 |
| Mark Begich | Alaska | Dem | 2014 |
| Jon Kyl | Arizona | GOP | 2012 |
| John McCain | Arizona | GOP | 2016 |
| John Boozman | Arkansas | GOP | 2016 |
| Mark Pryor | Arkansas | Dem | 2014 |
| Barbara Boxer | California | Dem | 2016 |
| Dianne Feinstein | California | Dem | 2012 |
| Mark Udall | Colorado | Dem | 2014 |
| Michael Bennet | Colorado | Dem | 2016 |
| Richard Blumenthal | Connecticut | Dem | 2016 |
| Joe Lieberman | Connecticut | Independent | 2012 |
| Thomas Carper | Delaware | Dem | 2012 |
| Chris Coons | Delaware | Dem | 2014 |
| Marco Rubio | Florida | GOP | 2016 |
| Bill Nelson | Florida | Dem | 2012 |
| Saxby Chambliss | Georgia | GOP | 2014 |
| Johnny Isakson | Georgia | GOP | 2016 |
| Daniel Akaka | Hawaii | Dem | 2012 |
| Daniel Inouye | Hawaii | Dem | 2016 |
| Michael Crapo | Idaho | GOP | 2016 |
| Jim Risch | Idaho | GOP | 2014 |
| Dick Durbin | Illinois | Dem | 2014 |
| Mark Kirk | Illinois | GOP | 2016 |
| Dan Coats | Indiana | GOP | 2016 |
| Richard Lugar | Indiana | GOP | 2012 |
| Charles Grassley | Iowa | GOP | 2016 |
| Tom Harkin | Iowa | Dem | 2014 |
| Jerry Moran | Kansas | Dem | 2016 |
| Pat Roberts | Kansas | GOP | 2014 |
| Rand Paul | Kentucky | GOP | 2016 |
| Mitch McConnell | Kentucky | GOP | 2014 |
| Mary Landrieu | Louisiana | Dem | 2014 |
| David Vitter | Louisiana | GOP | 2016 |
| Susan Collins | Maine | GOP | 2014 |
| Olympia Snowe | Maine | GOP | 2012 |
| Barbara Mikulski | Maryland | Dem | 2016 |
| Ben Cardin | Maryland | Dem | 2012 |
| Scott Brown | Massachusetts | GOP | 2012 |
| John Kerry | Massachusetts | Dem | 2014 |
| Carl Levin | Michigan | Dem | 2014 |
| Debbie Stabenow | Michigan | Dem | 2012 |
| Amy Klobuchar | Minnesota | Dem | 2012 |
| Al Franken | Minnesota | Dem | 2014 |
| Thad Cochran | Mississippi | GOP | 2014 |
| Roger Wicker | Mississippi | GOP | 2012 |
| Roy Blunt | Missouri | GOP | 2016 |
| Claire McCaskill | Missouri | Dem | 2012 |
| Max Baucus | Montana | Dem | 2014 |
| Jon Tester | Montana | Dem | 2012 |
| Mike Johanns | Nebraska | GOP | 2014 |
| Ben Nelson | Nebraska | Dem | 2012 |
| Dean Heller | Nevada | GOP | 2012 |
| Harry Reid | Nevada | Dem | 2016 |
| Kelly Ayotte | New Hampshire | GOP | 2016 |
| Jeanne Shaheen | New Hampshire | GOP | 2014 |
| Frank Lautenberg | New Jersey | Dem | 2014 |
| Robert Menendez | New Jersey | Dem | 2012 |
| Jeff Bingaman | New Mexico | Dem | 2012 |
| Tom Udall | New Mexico | Dem | 2014 |
| Kirsten Gillibrand | New York | Dem | 2016 |
| Chuck Schumer | New York | Dem | 2016 |
| Richard Burr | North Carolina | GOP | 2016 |
| Kay Hagan | North Carolina | Dem | 2014 |
| Kent Conrad | North Dakota | Dem | 2012 |
| Byron Dorgan | North Dakota | Dem | 2016 |
| Sherrod Brown | Ohio | Dem | 2012 |
| Rob Portman | Ohio | GOP | 2016 |
| Tom Coburn | Oklahoma | GOP | 2016 |
| James Inhofe | Oklahoma | GOP | 2014 |
| Ron Wyden | Oregon | Dem | 2016 |
| Jeff Merkley | Oregon | Dem | 2014 |
| Pat Toomey | Pennsylvania | GOP | 2016 |
| Bob Casey | Pennsylvania | Dem | 2012 |
| Sheldon Whitehouse | Rhode Island | Dem | 2012 |
| Jack Reed | Rhode Island | Dem | 2014 |
| Jim DeMint | South Carolina | GOP | 2016 |
| Lindsey Graham | South Carolina | GOP | 2014 |
| Tim Johnson | South Dakota | Dem | 2014 |
| John Thune | South Dakota | GOP | 2016 |
| Lamar Alexander | Tennessee | GOP | 2014 |
| Bob Corker | Tennessee | GOP | 2012 |
| John Cornyn | Texas | GOP | 2014 |
| Kay Bailey Hutchison | Texas | GOP | 2012 |
| Mike Lee | Utah | GOP | 2016 |
| Orrin Hatch | Utah | GOP | 2012 |
| Bernie Sanders | Vermont | Independent | 2012 |
| Patrick Leahy | Vermont | Dem | 2016 |
| Jim Webb | Virginia | Dem | 2012 |
| Mark Warner | Virginia | Dem | 2014 |
| Maria Cantwell | Washington | Dem | 2012 |
| Patty Murray | Washington | Dem | 2016 |
| Joe Manchin | West Virginia | Dem | 2012 |
| Jay Rockefeller | West Virginia | Dem | 2014 |
| Ron Johnson | Wisconsin | GOP | 2016 |
| Herb Kohl | Wisconsin | Dem | 2012 |
| Michael Enzi | Wyoming | GOP | 2014 |
| John Barrasso | Wyoming | GOP | 2012 |
Current Senate